Reading Time: 3 minutes The new build of Windows 10 have a lot of new security settings and some of them can make cause issues with VMware Workstation (or potentially also other host hypervisors). One common issue when you try to power on a VM in Workstation and instead you get this error message: VMware Workstation and Device/Credential Guard are not compatible. VMware Workstation can be run after disabling Device/Credential Guard.