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Like every hardware and software components, before apply a VMware vSphere upgrade or update you have to check all compatibility aspects. One is related to the backup software that can be critical because you may loose the capability to perform backup and/or restore.
Of course this apply also to “minor” update, like vSphere 8.0U3.
For Veeam Backup & Replication there is a specific Veeam KB (KB 2443) that provides information about compatibility between VMware vSphere and Veeam Backup & Replication.
And finally, some weeks after ESXi 8.0.3 become GA, there is an official support for vSphere 8.0U3 starting with Veeam Backup & Replication 12.1.2 (build 12.1.2.172)!
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